Počet záznamů: 1

Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: Efficient synthesis and antiviral activity

  1. 1.
    0361235 - UOCHB-X 2012 RIV GB eng J - Článek v odborném periodiku
    Hocková, Dana - Holý, Antonín - Andrei, G. - Snoeck, R. - Balzarini, J.
    Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: Efficient synthesis and antiviral activity.
    Bioorganic & Medicinal Chemistry. Roč. 19, č. 15 (2011), s. 4445-4453 ISSN 0968-0896
    Grant CEP: GA MŠk 1M0508; GA ČR GAP207/11/0108
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: drug design * purines * pyrimidines
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 2.921, rok: 2011

    Series of novel acyclic nucleoside phosphonates with various nucleobases and 2-(2-phosphonoethoxy)ethyl chain bearing various substituents in beta-position to the phosphonate moiety were prepared. The influence of structural alternations on antiviral activity was studied.
    Trvalý link: http://hdl.handle.net/11104/0198597