Počet záznamů: 1

Azido analogs of neuroactive steroids

  1. 1.
    0361126 - UOCHB-X 2012 RIV US eng J - Článek v odborném periodiku
    Vidrna, Lukáš - Černý, Ivan - Pouzar, Vladimír - Borovská, Jiřina - Vyklický, Vojtěch - Vyklický ml., Ladislav - Chodounská, Hana
    Azido analogs of neuroactive steroids.
    Steroids. Roč. 76, 10/11 (2011), s. 1043-1050 ISSN 0039-128X
    Grant CEP: GA MŠk(CZ) LC06077; GA MŠk(CZ) LC554; GA ČR(CZ) GA203/08/1498; GA ČR(CZ) GA309/07/0271
    Výzkumný záměr: CEZ:AV0Z40550506; CEZ:AV0Z50110509
    Klíčová slova: neuroactive steroids * synthesis * azides * NMDA receptor
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 2.829, rok: 2011

    Analogs of neurosteroid pregnanolone, modified in position 17 were prepared. Compounds with 20-keto pregnane side chain replaced completely or only partially by azide were synthesized and converted into corresponding sulfates. Tests for inhibition of glutamate induced response on NMDA receptors revealed retaining of the activity in some extent, three of sulfates tested were more active than parent compound.
    Trvalý link: http://hdl.handle.net/11104/0198523