Počet záznamů: 1

The synthesis of the 8-C-substituted 2,6-diamino-9-[2-(phosphonomethoxy)ethyl]purine (PMEDAP) derivatives by diverse cross-coupling reactions

  1. 1.
    0360763 - UOCHB-X 2012 RIV CA eng J - Článek v odborném periodiku
    Sedláček, Ondřej - Břehová, Petra - Pohl, Radek - Holý, Antonín - Janeba, Zlatko
    The synthesis of the 8-C-substituted 2,6-diamino-9-[2-(phosphonomethoxy)ethyl]purine (PMEDAP) derivatives by diverse cross-coupling reactions.
    Canadian Journal of Chemistry. Roč. 89, č. 4 (2011), s. 488-489 ISSN 0008-4042
    Grant CEP: GA MŠk 1M0508
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: acyclic nucleoside phosphonates * PMEDAP * cross-coupling * antiviral * antitumor
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 1.242, rok: 2011

    The synthesis of the 8-C-substituted 2,6-diamino-9-[2-(phosphonomethoxy)ethyl]purine (PMEDAP) analogues was performed from diisopropyl 8-bromo-2,6-diamino-9-[2-(phosphonomethoxy)ethyl]purine using Stille, Suzuki-Miyaura, Negishi, and Sonogashira cross-coupling reactions, as well as Pd-catalysed reactions with trialkylaluminiums.
    Trvalý link: http://hdl.handle.net/11104/0198236