Počet záznamů: 1

Tooth-bone morphogenesis during postnatal stages of mouse first molar development

  1. 1.
    0360057 - UZFG-Y 2012 RIV US eng J - Článek v odborném periodiku
    Lungová, V. - Radlanski, R.J. - Tucker, A. S. - Renz, H. - Míšek, Ivan - Matalová, Eva
    Tooth-bone morphogenesis during postnatal stages of mouse first molar development.
    Journal of Anatomy. Roč. 218, č. 6 (2011), s. 699-716 ISSN 0021-8782
    Grant CEP: GA ČR GC524/08/J032; GA MZd(CZ) NT11420
    Výzkumný záměr: CEZ:AV0Z50450515
    Klíčová slova: apoptosis * dentition * development
    Kód oboru RIV: EA - Morfologické obory a cytologie
    Impakt faktor: 2.370, rok: 2011

    The first mouse molar (M1) is the most common model for odontogenesis, with research particularly focused on prenatal development. However, the functional dentition forms postnatally, when the histogenesis and morphogenesis of the tooth is completed, the roots form and the tooth physically anchors into the jaw. In this work, M1 was studied from birth to eruption, assessing morphogenesis, proliferation and apoptosis, and correlating these with remodeling of the surrounding bony tissue. The M1 completed crown formation between postnatal (P) days 0-2, and the development of the tooth root was initiated at P4. From P2 until P12, cell proliferation in the dental epithelium reduced and shifted downward to the apical region of the forming root. In contrast, proliferation was maintained or increased in the mesenchymal cells of the dental follicle. At later stages, before tooth eruption (P20), cell proliferation suddenly ceased.
    Trvalý link: http://hdl.handle.net/11104/0197699