Počet záznamů: 1

Characterization of prolactin-releasing peptide: Binding, signaling and hormone secretion in rodent pituitary cell lines endogenously expressing its receptor

  1. 1.
    0359843 - UOCHB-X 2012 RIV US eng J - Článek v odborném periodiku
    Maixnerová, Jana - Špolcová, Andrea - Pýchová, Miroslava - Blechová, Miroslava - Elbert, Tomáš - Řezáčová, M. - Železná, Blanka - Maletínská, Lenka
    Characterization of prolactin-releasing peptide: Binding, signaling and hormone secretion in rodent pituitary cell lines endogenously expressing its receptor.
    Peptides. Roč. 32, č. 4 (2011), s. 811-817 ISSN 0196-9781
    Grant CEP: GA ČR GAP303/10/1368
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: PrRP * pituitary cell lines * food intake
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 2.434, rok: 2011

    The recently discovered prolactin-releasing peptide (PrRP) binds to the PrRP receptor and is involved in endocrine regulation and energy metabolism. However, its main physiological role is currently unknown. Two biologically active isoforms of PrRP exist: the 31 (PrRP31) and the 20 (PrRP20) amino acid forms, which both contain a C-terminal Phe amide sequence. In the present study, the PrRP receptor was immunodetected in three rodent tumor pituitary cell lines: GH3, AtT20 and RC-4B/C cells. Food intake after intracerebroventricular administration of PrRP analogs in fasted mice was followed. Both PrRP31 and PrRP20 decreased food intake, but PrRP13 did not show significant effect.
    Trvalý link: http://hdl.handle.net/11104/0197548