Počet záznamů: 1

Evolution and metabolic significance of the urea cycle in photosynthetic diatoms

  1. 1.
    0359538 - BC-A 2012 RIV GB eng J - Článek v odborném periodiku
    Allen, A. E. - Dupont, Ch. L. - Oborník, Miroslav - Horák, Aleš - Nunes-Nesi, A. - McCrow, J. P. - Zheng, H. - Johnson, D. A. - Hu, H. - Fernie, A. R. - Bowler, Ch.
    Evolution and metabolic significance of the urea cycle in photosynthetic diatoms.
    Nature. Roč. 473, č. 7346 (2011), s. 203-209 ISSN 0028-0836
    Grant CEP: GA ČR GA206/08/1423
    Výzkumný záměr: CEZ:AV0Z60220518
    Klíčová slova: CARBAMOYL-PHOSPHATE SYNTHETASE * PHAEODACTYLUM-TRICORNUTUM * MAXIMUM-LIKELIHOOD * PHYLOGENETIC RECONSTRUCTION * MOLECULAR EVOLUTION * SEQUENCE ALIGNMENT * DIVERGENCE TIMES * MARINE DIATOMS * MIXED MODELS * TREE
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 36.280, rok: 2011

    RNA-interference-mediated knockdown of a mitochondrial carbamoyl phosphate synthase impairs the response of nitrogen-limited diatoms to nitrogen addition. Intermediates in the ornithine-urea cycle are particularly depleted and both the tricarboxylic acid cycle and the glutamine synthetase/glutamate synthase cycles are linked directly with the ornithine-urea cycle. Several other metabolites are generated from this cycle by products of genes acquired from bacteria. So far, this cycle is only known for its essential role in the removal of fixed nitrogen in metazoans. In diatoms, this cycle serves as a distribution and repackaging hub for inorganic carbon and nitrogen and contributes significantly to the metabolic response of diatoms to episodic nitrogen availability. The diatomornithine-urea cycle therefore represents a key pathway for anaplerotic carbon fixation into nitrogenous compounds that are essential for diatom growth and for the contribution of diatoms to marine productivity.
    Trvalý link: http://hdl.handle.net/11104/0197312