Počet záznamů: 1

A new type of irreversibly reductively biodegradable hydrogel

  1. 1.
    0359453 - UMCH-V 2012 RIV NL eng J - Článek v odborném periodiku
    Vetrík, Miroslav - Hrubý, Martin - Přádný, Martin - Michálek, Jiří
    A new type of irreversibly reductively biodegradable hydrogel.
    Polymer Degradation and Stability. Roč. 96, č. 5 (2011), s. 892-897 ISSN 0141-3910
    Grant CEP: GA ČR GAP108/10/1560; GA ČR GPP207/10/P054; GA MŠk 1M0538
    Výzkumný záměr: CEZ:AV0Z40500505
    Klíčová slova: biodegradable hydrogel * disulfide * L-cysteine
    Kód oboru RIV: CD - Makromolekulární chemie
    Impakt faktor: 2.769, rok: 2011

    Reductively biodegradable hydrogels based on poly[N-(2-hydroxypropyl)methacrylamide] crosslinked with N-[3-(methacryloylamino)propyl] -6-{[5-({[3-(methacryloylamino)propyl]amino}carbonyl)-2-pyridyl]disulfanyl}nicotinamide intended for tissue engineering were synthesized and characterized. The rate of irreversible reductive degradation with thiol l-cysteine (a model of human body where several thiols are present in extracellular space) was studied using several l-cysteine concentrations. The mechanism of the irreversible reductive bond cleavage in the crosslinker structure was confirmed on a low-molecular-weight model. The hydrogel is stable during storage in phosphate buffered saline and is degraded relatively quickly in a concentration-dependent manner after addition of l-cysteine to the surrounding medium.
    Trvalý link: http://hdl.handle.net/11104/0197239