Počet záznamů: 1

The inhibitor of cyclin-dependent kinases, olomoucine II, exhibits potent antiviral properties

  1. 1.
    0359317 - UEB-Q 2011 RIV GB eng J - Článek v odborném periodiku
    Holčáková, J. - Tomašec, P. - Burget, J. J. - Wang, E. C. Y. - Wilkinson, G. W. G. - Hrstka, R. - Kryštof, Vladimír - Strnad, Miroslav - Vojtešek, B.
    The inhibitor of cyclin-dependent kinases, olomoucine II, exhibits potent antiviral properties.
    Antiviral Chemistry and Chemotherapy. Roč. 20, č. 3 (2010), s. 133-142 ISSN 0956-3202
    Grant CEP: GA ČR GA301/08/1649
    Výzkumný záměr: CEZ:AV0Z50380511
    Klíčová slova: Cyclin-dependent Kinase * Olomoucine II * vaccinia
    Kód oboru RIV: EE - Mikrobiologie, virologie

    Olomoucine II, the most recent derivative of roscovitine, is an exceptionally potent pharmacological inhibitor of cyclin-dependent kinase activities. Here, we report that olomoucine II is also an effective antiviral agent. Olomoucine II inhibited replication of a broad range of wild-type human viruses, including herpes simplex virus, human adenovirus type-4 and human cytomegalovirus. Olomoucine II also inhibited replication of vaccinia virus and herpes simplex virus mutants resistant to conventional acyclovir treatment. This report is the first demonstration of a poxvirus being sensitive to a cyclin-dependent kinase inhibitor. The antiviral effects of olomoucine II could be observed at lower concentrations than with roscovitine, although both were short-term. A remarkable observation was that olomoucine II, when used in combination with the DNA polymerase inhibitor cidofovir, was able to almost completely eliminate the spread of infectious adenovirus type-4 progeny from infected cells.
    Trvalý link: http://hdl.handle.net/11104/0197120