Počet záznamů: 1

Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting

  1. 1.
    0359227 - UMCH-V 2012 RIV NL eng J - Článek v odborném periodiku
    Etrych, Tomáš - Strohalm, Jiří - Chytil, Petr - Černoch, Peter - Starovoytova, Larisa - Pechar, Michal - Ulbrich, Karel
    Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting.
    European Journal of Pharmaceutical Sciences. Roč. 42, č. 5 (2011), s. 527-539 ISSN 0928-0987
    Grant CEP: GA AV ČR IAA400500806; GA AV ČR IAAX00500803; GA ČR GA203/08/0543
    Výzkumný záměr: CEZ:AV0Z40500505
    Klíčová slova: dendrimer * HPMA copolymers * doxorubicin
    Kód oboru RIV: CD - Makromolekulární chemie
    Impakt faktor: 3.212, rok: 2011

    New biodegradable star polymer–doxorubicin conjugates designed for passive tumor targeting were investigated and the present study described their synthesis, physico-chemical characterization, drug release and biodegradation. In the conjugates the core formed by poly(amido amine) dendrimers was grafted with semitelechelic N-(2-hydroxypropyl)methacrylamide copolymers bearing doxorubicin attached by hydrazone bonds, which enabled intracellular pH-controlled drug release, or by a GFLG sequence, which was susceptible to enzymatic degradation. The controlled synthesis utilizing semitelechelic copolymer precursors facilitated preparation of biodegradable polymer conjugates in a broad range of molecular weights (110–295 kD). The polymer grafts were attached to the dendrimers either through stable amide bonds or enzymatically or reductively degradable spacers, which enabled intracellular degradation of the HMW polymer carrier to products that were able to be excreted by glomerular filtration.
    Trvalý link: http://hdl.handle.net/11104/0006435