Počet záznamů: 1

Enzymatic degradation of the hydrogels based on synthetic poly(.alpha.-amino acid)s

  1. 1.
    0359220 - UMCH-V 2012 RIV GB eng J - Článek v odborném periodiku
    Sedlačík, Tomáš - Studenovská, Hana - Rypáček, František
    Enzymatic degradation of the hydrogels based on synthetic poly(.alpha.-amino acid)s.
    Journal of Materials Science-Materials in Medicine. Roč. 22, č. 4 (2011), s. 781-788 ISSN 0957-4530
    Grant CEP: GA MŠk 1M0538; GA AV ČR KJB400500801; GA ČR GP203/04/P124
    Výzkumný záměr: CEZ:AV0Z40500505
    Klíčová slova: PHEG and copolymers * poly(alpha-amino acid)s * hydrogels
    Kód oboru RIV: CD - Makromolekulární chemie
    Impakt faktor: 2.316, rok: 2011

    Biodegradable hydrogels are studied as potential scaffolds for soft tissue regeneration. In this work biodegradable hydrogels were prepared from synthetic poly (a-amino acid)s, poly(AA)s. The covalently crosslinked gels were formed by radical copolymerization of methacryloylated poly(AA)s, e.g. poly[N5-(2-hydroxy-ethyl)-L-Glu- ran-L-Ala-ran-N6-methacryloyl-L-Lys], as a multifunctional macromer with a low-molecular-weight methacrylic monofunctional monomer, e.g. HEMA. Due to their polypeptide backbone, synthetic poly(AA)s are cleavable in biological environment by enzyme-catalyzed hydrolysis. The feasibility of enzymatic degradation of poly(AA)s alone and the hydrogels made from them was studied using elastase, a matrix proteinase involved in tissue healing processes, as a model enzyme. Specificity of elastase for cleavage of polypeptide chains behind the L-Ala residues was reflected in faster degradation of L-Ala-containing copolymers as well as of hydrogels composed of them.
    Trvalý link: http://hdl.handle.net/11104/0197049