Počet záznamů: 1

Automatic Formation of Hypotheses on the Relationships between Structure of Naphthalene Analogs and Bioluminescence Response of Bioreporter Pseudomonas fluorescens HK44

  1. 1.
    0359054 - UCHP-M 2012 RIV CZ eng J - Článek v odborném periodiku
    Trögl, J. - Hálová, J. - Kuncová, Gabriela - Pařík, P.
    Automatic Formation of Hypotheses on the Relationships between Structure of Naphthalene Analogs and Bioluminescence Response of Bioreporter Pseudomonas fluorescens HK44.
    Folia Microbiologica. Roč. 55, č. 5 (2010), s. 411-417 ISSN 0015-5632
    Grant CEP: GA MŠk OC 121
    Výzkumný záměr: CEZ:AV0Z40720504
    Klíčová slova: substituted naphthalenes * bioconversion * optical biosensor
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 0.977, rok: 2010

    Seven hypotheses on relationships between the structure of naphthalene analogs and bioluminescence response of bioreporter Pseudomonas fluorescens were formulated using GUHA (General Unary Hypotheses Automaton) on a training set of 37 compounds. Prediction of bioluminescence response of 12 new naphthalene analogs was successful in 69 % cases and resulted in rejection of single hypothesis. The results demonstrate applicability of GUHA in structure-activity research, especially for qualitative data.
    Trvalý link: http://hdl.handle.net/11104/0196924