Počet záznamů: 1

The Synthesis and Conformation of Dihydroxypiperidinyl Derivates of Nucleobases as Novel Iminosugar Nucleoside Analogs

  1. 1.
    0359047 - UOCHB-X 2012 RIV DE eng J - Článek v odborném periodiku
    Rejman, Dominik - Pohl, Radek - Dračínský, Martin
    The Synthesis and Conformation of Dihydroxypiperidinyl Derivates of Nucleobases as Novel Iminosugar Nucleoside Analogs.
    European Journal of Organic Chemistry. -, č. 11 (2011), s. 2172-2187 ISSN 1434-193X
    Grant CEP: GA MŠk(CZ) LC06077; GA MŠk 2B06065; GA AV ČR KJB400550903
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: iminosugars * azanucleosides * nucleosides
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 3.329, rok: 2011

    An optimized method for the synthesis of an important chiral scaffold, was developed. Using this intermediate, the preparation of various chiral aminodihydroxypiperidines and their transformation into a series of non-glycosidic, six-membered azanucleosides was accomplished. NMR conformation analysis of the prepared piperidine azanucleosides revealed a preference for the chair conformation, with the nucleobase fixed in the equatorial position in all cases.
    Trvalý link: http://hdl.handle.net/11104/0196920