Počet záznamů: 1

Differential effects of indirubin and 2,3,7,8-tetrachlorodibenzo-p-dioxin on the aryl hydrocarbon receptor (AhR) signalling in liver progenitor cells

  1. 1.
    0359013 - BFU-R 2012 RIV NL eng J - Článek v odborném periodiku
    Procházková, Jiřina - Kozubík, Alois - Machala, M. - Vondráček, Jan
    Differential effects of indirubin and 2,3,7,8-tetrachlorodibenzo-p-dioxin on the aryl hydrocarbon receptor (AhR) signalling in liver progenitor cells.
    Toxicology. Roč. 279, 1-3 (2011), s. 146-154 ISSN 0300-483X
    Grant CEP: GA ČR(CZ) GA524/06/0517
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: indirubin * aryl hydrocarbon receptor * plakoglobin
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 3.681, rok: 2011

    Effects of indirubin, a putative novel ligand of aryl hydrocarbon receptor, had been tested in an in vitro model of rat oval cells, and compared with the effects of model toxic ligand, TCDD. We observed dose-sependent differences in indirubin action on AhR activation and on expression of selected genes known to be regulated by AhR/ARNT signaling pathway.
    Trvalý link: http://hdl.handle.net/11104/0196892