Počet záznamů: 1

A “Cute” Desensitization of TRPV1

  1. 1.
    0358917 - FGU-C 2012 RIV NL eng J - Článek v odborném periodiku
    Touška, Filip - Maršáková, Lenka - Teisinger, Jan - Vlachová, Viktorie
    A “Cute” Desensitization of TRPV1.
    Current Pharmaceutical Biotechnology. Roč. 12, č. 1 (2011), s. 122-129 ISSN 1389-2010
    Grant CEP: GA ČR GA305/09/0081; GA ČR(CZ) GAP301/10/1159; GA AV ČR(CZ) IAA600110701; GA MŠk(CZ) 1M0517; GA MŠk(CZ) LC554
    Grant ostatní: Univerzita Karlova(CZ) 43-259 052
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: capsaicin * analgesia * vanilloid receptor
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 2.805, rok: 2011

    Upon stimulation, the calcium influx via the vanilloid TRPV1 channels acutely desensitizes the channels themselves, which, from the cellular point of view, represents a feedback mechanism protecting the nociceptive neuron from toxic calcium overload. This review attempts to cover historical aspects of research into this process, tries to highlight some new challenging thoughts on the important phenomenon of TRPV1 desensitization and focuses on the putative molecular mechanisms that are thought to account for the acute phase of this process (‘acute desensitization’)
    Trvalý link: http://hdl.handle.net/11104/0196825