Počet záznamů: 1

Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer´s disease

  1. 1.
    0357625 - UEM-P 2011 RIV GB eng J - Článek v odborném periodiku
    Rodríguez Arellano, Jose Julio - Witton, J. - Olabarria, M. - Noristani, H. N. - Verkhratsky, Alexei
    Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer´s disease.
    Cell Death & Disease. Roč. 1, č. 1 (2010), e1-e6 ISSN 2041-4889
    Grant CEP: GA ČR GA309/09/1696; GA ČR GA305/08/1384
    Výzkumný záměr: CEZ:AV0Z50390703
    Klíčová slova: microglia * Alzheimer´s disease * hippocampus
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy

    Our results show for the first time that the increase in the density of resting microglia precedes both plaque formation and activation of microglia by extracellular Aβ accumulation. We suggest that AD pathology triggers a complex microglial reaction: at the initial stages of the disease the number of resting microglia increases, as if in preparation for the ensuing activation in an attempt to fight the extracellular Aβ load that is characteristic of the terminal stages of the disease.
    Trvalý link: http://hdl.handle.net/11104/0195858