Počet záznamů: 1

Azacytosine Derivatives Useful as Antiviral Agents

  1. 1.
    0356428 - UOCHB-X 2011 RIV DE eng P - Patentový dokument
    Holý, Antonín - Krečmerová, Marcela - Pískala, Alois - Andrei, G. - Snoeck, R. - De Clercq, E. - Neyts, J. - Naesens, L.
    Azacytosine Derivatives Useful as Antiviral Agents.
    Munich: European Patent Office, 2010. Vlastník: Ústav organické chemie a biochemie AV ČR, v. v. i. - K.U. Leuven Research and Development, Leuven, BE. Datum udělení patentu: 10.11.2010. Číslo patentu: EP1966226
    Grant CEP: GA MŠk 1M0508
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: 5-azacytosine * triazine * antivirals * acyclic nucleoside phosphonates
    Kód oboru RIV: CC - Organická chemie
    http://v3.espacenet.com/publicationDetails/originalDocument?FT=D&date=20101110&DB=EPODOC&locale=en_EP&CC=EP&NR=1966226B1&KC=B1

    1-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine (HPMP-5-azaC), its cyclic form and a series of ester prodrugs were prepared as a new type of antiviral agents active against all species of DNA viruses in vitro and in vivo. HPMP-5-azaC showed a 2- to 16-fold higher antiviral selectivity index compared to cidofovir.
    Trvalý link: http://hdl.handle.net/11104/0194953