Počet záznamů: 1
The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1
- 1.0356171 - FGÚ 2011 RIV GB eng J - Článek v odborném periodiku
Samad, Abdul - Surá, Lucie - Benedikt, Jan - Ettrich, Rüdiger - Minofar, Babak - Teisinger, Jan - Vlachová, Viktorie
The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1.
Biochemical Journal. Roč. 433, č. 1 (2011), s. 197-204. ISSN 0264-6021. E-ISSN 1470-8728
Grant CEP: GA ČR(CZ) GA305/06/0319; GA ČR GAP301/10/1159; GA AV ČR(CZ) IAA600110701; GA MŠMT(CZ) LC554; GA MŠMT(CZ) 1M0517
Grant ostatní: GA MŠk(CZ) LC06010; GA MŠk(CZ) SVV-2010-261304
Program: LC
Výzkumný záměr: CEZ:AV0Z50110509; CEZ:AV0Z60870520
Klíčová slova: ankyrin receptor * transient receptor channel * voltage sensor
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 4.897, rok: 2011
The ankyrin transient receptor potential channel TRPA1 is a nonselective cationic channel that is expressed by sensory neurons, where it can be activated by pungent chemicals, such as allyl isothiocyanate (AITC) or highly depolarizing voltages (> +100 mV). In this study, we mutated 27 basic residues all along the C-terminal tail of TRPA1 and explored their role in AITC and voltage-dependent gating. We identify basic residues in the C-terminus that are strongly involved in TRPA1 voltage and chemical sensitivity, some of them may represent possible interaction sites for negatively charged molecules that are generally considered to modulate TRPA1
Trvalý link: http://hdl.handle.net/11104/0194765
Počet záznamů: 1