Počet záznamů: 1

The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1

  1. 1.
    0356171 - FGU-C 2011 RIV GB eng J - Článek v odborném periodiku
    Samad, Abdul - Surá, Lucie - Benedikt, Jan - Ettrich, Rüdiger - Minofar, Babak - Teisinger, Jan - Vlachová, Viktorie
    The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1.
    Biochemical Journal. Roč. 433, č. 1 (2011), s. 197-204 ISSN 0264-6021
    Grant CEP: GA ČR(CZ) GA305/06/0319; GA ČR GAP301/10/1159; GA AV ČR(CZ) IAA600110701; GA MŠk(CZ) LC554; GA MŠk(CZ) 1M0517
    Grant ostatní: GA MŠk(CZ) LC06010; GA MŠk(CZ) SVV-2010-261304
    Výzkumný záměr: CEZ:AV0Z50110509; CEZ:AV0Z60870520
    Klíčová slova: ankyrin receptor * transient receptor channel * voltage sensor
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 4.897, rok: 2011

    The ankyrin transient receptor potential channel TRPA1 is a nonselective cationic channel that is expressed by sensory neurons, where it can be activated by pungent chemicals, such as allyl isothiocyanate (AITC) or highly depolarizing voltages (> +100 mV). In this study, we mutated 27 basic residues all along the C-terminal tail of TRPA1 and explored their role in AITC and voltage-dependent gating. We identify basic residues in the C-terminus that are strongly involved in TRPA1 voltage and chemical sensitivity, some of them may represent possible interaction sites for negatively charged molecules that are generally considered to modulate TRPA1
    Trvalý link: http://hdl.handle.net/11104/0194765