Počet záznamů: 1

Conservation and diversification of an ancestral chordate gene regulatory network for dorsoventral patterning

  1. 1.
    0355826 - UMG-J 2011 RIV US eng J - Článek v odborném periodiku
    Kozmiková, Iryna - Smolíková, Jana - Vlček, Čestmír - Kozmik, Zbyněk
    Conservation and diversification of an ancestral chordate gene regulatory network for dorsoventral patterning.
    PLoS ONE. Roč. 6, č. 2 (2011), e14650 E-ISSN 1932-6203
    Grant CEP: GA AV ČR IAA500520604; GA AV ČR IAA500520908
    Výzkumný záměr: CEZ:AV0Z50520514
    Klíčová slova: Wnt Bmp * amphioxus * axial patterning
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 4.092, rok: 2011

    Formation of a dorsoventral axis is a key event in the early development of most animal embryos. It is well established that bone morphogenetic proteins (Bmps) and Wnts are key mediators of dorsoventral patterning in vertebrates. In the cephalochordate amphioxus, genes encoding Bmps and transcription factors downstream of Bmp signaling such as Vent are expressed in patterns reminiscent of those of their vertebrate orthologues. We found that Bmp but not canonical Wnt signaling regulates promoters of genes encoding homeodomain proteins AmphiVent1 and AmphiVent2. Our data indicate high evolutionary conservation of a core Bmp-triggered gene regulatory network for dorsoventral patterning in chordates and suggest that co-option of the canonical Wnt signaling pathway for dorsoventral patterning in vertebrates represents one of the innovations through which an increased morphological complexity of vertebrate embryo is achieved.
    Trvalý link: http://hdl.handle.net/11104/0194506
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