Počet záznamů: 1

Knockdown of F1 epsilon subunit decreases mitochondrial content of ATP synthase and leads to accumulation of subunit c

  1. 1.
    0355560 - FGU-C 2011 RIV NL eng J - Článek v odborném periodiku
    Havlíčková, Vendula - Kaplanová, Vilma - Nůsková, Hana - Drahota, Zdeněk - Houštěk, Josef
    Knockdown of F1 epsilon subunit decreases mitochondrial content of ATP synthase and leads to accumulation of subunit c.
    Biochimica Et Biophysica Acta-Bioenergetics. Roč. 1797, 6-7 (2010), s. 1124-1129 ISSN 0005-2728.
    [European Bioenergetics Conference /16./. Warsaw, 17.07.2010-22.07.2010]
    Grant CEP: GA MŠk(CZ) 1M0520; GA MZd(CZ) NS9759
    Grant ostatní: Univerzita Karlova(CZ) 97807
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: ATP synthase * biogenesis * mitochondria
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 5.132, rok: 2010

    Silencing in HEK293 cell line by RNAi of ATP5E gene encoding the epsilon subunit resulted in inhibition of biogenesis of ATP synthase and accumulation of hydrophobic subunit c of the rotor structure of the enzyme. Results indicate a regulatory role of the smallest subunit of the catalytic F1 part of the enzyme in biosynthesis and assembly of mammalian ATP synthase complex
    Trvalý link: http://hdl.handle.net/11104/0194304