Počet záznamů: 1

Pharmacological Evaluation of the Long-Term Effects of Xanomeline on the M1 Muscarinic Acetylcholine Receptor

  1. 1.
    0355377 - FGU-C 2011 RIV US eng J - Článek v odborném periodiku
    Grant, M.K.O. - Noetzel, M.J. - De Lorme, K.C. - Jakubík, Jan - Doležal, Vladimír - El-Fakahany, E. E.
    Pharmacological Evaluation of the Long-Term Effects of Xanomeline on the M1 Muscarinic Acetylcholine Receptor.
    PLoS ONE. Roč. 5, č. 12 (2010), e15722-16 E-ISSN 1932-6203
    Grant CEP: GA ČR GA305/09/0681
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: Xanomeline * muscarinic acetylcholine receptor
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 4.411, rok: 2010

    Additional data indicated that blockade of the receptor orthosteric site or the use of a non-functional receptor mutant reversed the long-term effects of xanomeline, but not its persistent binding at an allosteric site. Furthemore, the long-term effects of xanomeline on the receptor are mainly due to receptor down-regulation rather than internalization
    Trvalý link: http://hdl.handle.net/11104/0194161