Počet záznamů: 1

NF449 is a novel inhibitor of fibroblast growth factor receptor 3 (FGFR3) signaling active in chondrocytes and multiple myeloma cells

  1. 1.
    0355236 - BFU-R 2011 RIV US eng J - Článek v odborném periodiku
    Krejčí, Pavel - Murakami, S. - Procházková, J. - Trantírek, L. - Chlebová, K. - Ouyang, Z. - Aklian, A. - Smutný, J. - Bryja, Vítězslav - Kozubík, Alois - Wilcox, W.R.
    NF449 is a novel inhibitor of fibroblast growth factor receptor 3 (FGFR3) signaling active in chondrocytes and multiple myeloma cells.
    Journal of Biological Chemistry. Roč. 285, č. 27 (2010), s. 20644-20653 ISSN 0021-9258
    Grant ostatní: GA ČR(CZ) GA301/09/0587
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: NF449 * fibroblast growth factor receptor * antagonist
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 5.328, rok: 2010

    This article indentifies, for the first time, a NF449 compound as a novel inhibitor of FGFR3 signal transduction in vitro and in vivo. Various molecular aspects of NF449 action are described and discussed in the article, such as its effects on FGFR3 kinase activity, activation of downstream signaling molecules as well as effects on several cellular phenotypes regulated by FGFR3 signaling.
    Trvalý link: http://hdl.handle.net/11104/0194054