Počet záznamů: 1

Neoplastic progression of the human breast cancer cell line G3S1 is associated with elevation of cytoskeletal dynamics and upregulation of MT1-MMP

  1. 1.
    0355190 - UMG-J 2011 RIV GR eng J - Článek v odborném periodiku
    Tolde, O. - Rosel, D. - Mierke, C.T. - Paňková, D. - Folk, P. - Veselý, Pavel - Brabek, J.
    Neoplastic progression of the human breast cancer cell line G3S1 is associated with elevation of cytoskeletal dynamics and upregulation of MT1-MMP.
    International Journal of Oncology. Roč. 36, č. 4 (2010), s. 833-839 ISSN 1019-6439
    Grant CEP: GA MŠk(CZ) LC06061
    Výzkumný záměr: CEZ:AV0Z50520514
    Klíčová slova: invasiveness * neoplastic progression * cytoskeletal dynamics
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 2.571, rok: 2010

    The newly established breast cancer cell line G3S1, derived from EM-G3 breast cancer progenitors. was analyzed for functional changes related to neoplastic progression manifested by elevated invasiveness and enhanced capability to degrade gelatin. Degradation of gelatin and invasiveness of G3S1 cells was found to be dependent on the activity of matrix proteinases and actin cytoskeletal dynamics. Therefore, the expression and activity of these proteases was compared in G3S1 and EM-G3 cells. Despite enhanced capability of G3S1 cells to degrade gelatin. these cells exhibited lower levels of secreted extracellular matrix degrading proteases than parental EM-G3 cells. However, the expression of membrane-bound MT1-MMP was strongly elevated in G3S1 cells. While the degradation of gelatin was associated with invadopodia-like structures in both EM-G3 and G3S1 cells, the cytoskeletal remodeling dynamics was greatly elevated in G3S1 cells.
    Trvalý link: http://hdl.handle.net/11104/0194017