Počet záznamů: 1

NK1.1+ cells are important for the development of protective immunity against MHC I-deficient, HPV16-associated tumours

  1. 1.
    0355110 - UMG-J 2011 RIV GR eng J - Článek v odborném periodiku
    Indrová, Marie - Šímová, Jana - Bieblová, Jana - Bubeník, Jan - Reiniš, Milan
    NK1.1+ cells are important for the development of protective immunity against MHC I-deficient, HPV16-associated tumours.
    Oncology Reports. Roč. 25, č. 1 (2011), s. 281-288 ISSN 1021-335X
    Grant CEP: GA AV ČR IAA500520807
    Grant ostatní:EU-FP6-NOE(XE) Project 018933
    Výzkumný záměr: CEZ:AV0Z50520514
    Klíčová slova: MHC class I-deficient tumours * CD8+, CD4+, NK1.1+cell subpopulations * interferon gamma
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 1.835, rok: 2011

    In vivo depletion of CD8+ cells resulted in complete elimination of protective effects after immunization with TC-1 cells (MHC class I+) against the TC-1 tumour challenge. After immunization with TC-1/A9 or MK16 tumour cells (MHC class I-deficient) a remarkable dependence on the presence of NK1.1+ cells was observed, Cytotoxic activity induced by TC-1 cell immunization was abrogated in CD8+ cell-depleted mice and the mice showed similar percentage of IFNgamma-producing cells in CD8+, CD4+ and NK1.1+ subpopulations.. After MK16 or TC-1/A9 cell immunization, NK1.1+ displayed significant reduction of cytotoxicity. The highest proportion of IFNgamma-producing cells was concentrated into the NK1.1+ cells..
    Trvalý link: http://hdl.handle.net/11104/0193953