Počet záznamů: 1

Up-regulation and redistribution of protein kinase C-delta in chronically hypoxic heart

  1. 1.
    0354866 - FGU-C 2011 RIV US eng J - Článek v odborném periodiku
    Hlaváčková, M. - Kožichová, K. - Neckář, Jan - Kolář, František - Musters, R.J.P. - Novák, O. - Nováková, O.
    Up-regulation and redistribution of protein kinase C-delta in chronically hypoxic heart.
    Molecular and Cellular Biochemistry. Roč. 345, 1-2 (2010), s. 271-282 ISSN 0300-8177
    Grant CEP: GA ČR(CZ) GA305/07/0875; GA MŠk(CZ) 1M0510
    Grant ostatní: Univerzita Karlova(CZ) 97908
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: protein kinase C * chronic intermittent hypoxia * heart
    Kód oboru RIV: ED - Fyziologie
    Impakt faktor: 2.168, rok: 2010

    The aim of the study was to examine the effects of chronic intermittent hypoxia (CIH) and acute administration of PKC-delta inhibitor rottlerin on the expression and subcellular distribution of PKC-delta and PKC-epsilon in the left ventricular myocardium in rats. It has been shown that CIH up-regulated PKC-delta which was localized to mitochondrial and sarcolemmal membranes. The inhibitory effects of rottlerin on PKC-delta subcellular redistribution and cardioprotection (as shown previously) support the view that this isoform plays a role in the mechanism of CIH-induced ischemic tolerance
    Trvalý link: http://hdl.handle.net/11104/0193773