Počet záznamů: 1

Alterations of NO synthase isoforms in brain and kidney of rats with genetic and salt hypertension

  1. 1.
    0353982 - FGU-C 2011 RIV CZ eng J - Článek v odborném periodiku
    Hojná, Silvie - Kuneš, Jaroslav - Zicha, Josef
    Alterations of NO synthase isoforms in brain and kidney of rats with genetic and salt hypertension.
    Physiological Research. Roč. 59, č. 6 (2010), s. 997-1009 ISSN 0862-8408
    Grant CEP: GA MŠk(CZ) 1M0510; GA ČR(CZ) GA305/08/0139
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: brainstem * diencephalon * kidney
    Kód oboru RIV: ED - Fyziologie
    Impakt faktor: 1.646, rok: 2010

    Our study evaluated NO synthase (NOS) activity and protein expression of its three isoforms - neuronal (nNOS), endothelial NOS (eNOS) and inducible (iNOS) - in two brain regions involved in blood pressure control (diencephalon and brainstem) as well as in the kidney of rats with either genetic (SHR) or salt-induced hypertension (Dahl rats). We disclosed similar changes of NO system in the brainstem (but not in the diencephalon) of rats with genetic and salt-induced hypertension. Decreased nNOS expression was associated with increased blood pressure due to enhanced sympathetic tone
    Trvalý link: http://hdl.handle.net/11104/0193081