Počet záznamů: 1

Micronuclei in neonates and children: effects of environmental, genetic, demographic and disease variables

  1. 1.
    0353971 - UEM-P 2011 RIV GB eng J - Článek v odborném periodiku
    Holland, N. - Fucic, A. - Merlo, D.F. - Šrám, Radim - Kirsch-Volders, M.
    Micronuclei in neonates and children: effects of environmental, genetic, demographic and disease variables.
    Mutagenesis. Roč. 26, č. 1 (2011), s. 51-56 ISSN 0267-8357
    Grant CEP: GA MŽP(CZ) SP/1B3/8/08
    Grant ostatní: European Union(XE) FOOD-CT-2005-513943; European Union(XE) FOOD-CT-2005-016320
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: Micronucleus assay * newborns * children
    Kód oboru RIV: DN - Vliv životního prostředí na zdraví
    Impakt faktor: 3.183, rok: 2011

    This is an overview of the micronucleus (MN) assay in lymphocytes and exfoliated epithelial cells of children from birth to adolescence. The article briefly describes the effect of age and sex in different cell types, the use of the MN assay for monitoring of environmental exposures and characterisation of MN levels in children with various diseases and their treatment. The relationship of MN as biomarkers of genotoxicity with other markers, such as genetic polymorphisms and gene expression is also discussed. In the last section, an attempt was made to summarize the current state of knowledge and significant achievements in genotoxicity research in children.
    Trvalý link: http://hdl.handle.net/11104/0193071