Počet záznamů: 1

Structural dynamics of thrombin-binding DNA aptamer d(GGTTGGTGTGGTTGG) quadruplex DNA studied by large-scale explicit solvent simulations

  1. 1.
    0353799 - BFU-R 2011 RIV US eng J - Článek v odborném periodiku
    Reshetnikov, R. - Golovin, A. - Spiridonova, V. - Kopylov, A. - Šponer, Jiří
    Structural dynamics of thrombin-binding DNA aptamer d(GGTTGGTGTGGTTGG) quadruplex DNA studied by large-scale explicit solvent simulations.
    Journal of Chemical Theory and Computation. Roč. 6, č. 10 (2010), s. 3003-3014 ISSN 1549-9618
    Grant CEP: GA AV ČR(CZ) IAA400040802; GA ČR(CZ) GA203/09/1476; GA MŠk(CZ) LC06030
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: molecular dynamics * quadruplex DNA * thrombin
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 5.138, rok: 2010

    The thrombin-binding aptamer (15-TBA) is a 15-mer DNA oligonucleotide with sequence d(GGTTGGTGTGGTTGG). 15-TBA folds into a quadruplex DNA (G-DNA) structure with two planar G-quartets connected by three single-stranded loops. In the present study, the explicit solvent molecular dynamics (MD) simulation method was utilized to analyze the 15-TBA-thrombin threedimensional structure.
    Trvalý link: http://hdl.handle.net/11104/0192943