Počet záznamů: 1

Different features of the DNA binding mode of antitumor cis-amminedichlorido(cyclohexylamine)platinum(II) (JM118) and cisplatin in vitro

  1. 1.
    0353781 - BFU-R 2011 RIV US eng J - Článek v odborném periodiku
    Kostrhunová, Hana - Vrána, Oldřich - Suchánková, T. - Gibson, D. - Kašpárková, Jana - Brabec, Viktor
    Different features of the DNA binding mode of antitumor cis-amminedichlorido(cyclohexylamine)platinum(II) (JM118) and cisplatin in vitro.
    Chemical Research in Toxicology. Roč. 23, č. 11 (2010), s. 1833-1842 ISSN 0893-228X
    Grant CEP: GA MŠk(CZ) ME08017; GA MŠk(CZ) ME10066; GA MŠk(CZ) OC08003; GA AV ČR(CZ) IAA400040803; GA ČR(CZ) GAP301/10/0598
    Grant ostatní: GA MŠk(CZ) LC06030; GA MŠk(CZ) OC09018; GA AV ČR(CZ) KAN200200651
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: JM118 * DNA bending * DNA-protein cross-linking
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 4.148, rok: 2010

    JM118 is the major metabolite of satraplatin. The results of DNA-protein cross-linking assay and DNA repair synthesis by cell-free extract showed a higher DNA-protein cross-linking efficiency of JM118 and less efficient removal from DNA of the adducts of JM118 in comparison with cisplatin.
    Trvalý link: http://hdl.handle.net/11104/0192929