Počet záznamů: 1

Studies on cellular accumulation of satraplatin and its major metabolite JM118 and their interactions with glutathione

  1. 1.
    0353777 - BFU-R 2011 RIV US eng J - Článek v odborném periodiku
    Kostrhunová, Hana - Kašpárková, Jana - Gibson, D. - Brabec, Viktor
    Studies on cellular accumulation of satraplatin and its major metabolite JM118 and their interactions with glutathione.
    MOLECULAR PHARMACEUTICS. Roč. 7, č. 6 (2010), s. 2093-2102 ISSN 1543-8384
    Grant CEP: GA MŠk(CZ) ME08017; GA MŠk(CZ) ME10066; GA MŠk(CZ) OC08003; GA AV ČR(CZ) IAA400040803; GA ČR(CZ) GAP301/10/0598
    Grant ostatní: GA MŠk(CZ) LC06030; GA AV ČR(CZ) KAN200200651
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: JM118 * cellular accumulation * glutathione
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 5.400, rok: 2010

    The organic cation transporters play a more important role in the mechanism of cytotoxicity of JM118 than in the cytotoxicity of cisplatin. Satraplatin is a poor substrate of these transporters. Satraplatin reacts with glutathione with the rate markedly lower than JM118 and cisplatin. Satraplatin can be activated by glutathione allowing it to react with DNA.
    Trvalý link: http://hdl.handle.net/11104/0006241