Počet záznamů: 1

Synthesis and Evaluation of Biological Activity of the Quaternary Ammonium Salts of Lupane-, Oleanane-, and Ursane-Type Acids

  1. 1.
    0352909 - MBU-M 2011 RIV DE eng J - Článek v odborném periodiku
    Biedermann, David - Eignerová, B. - Hajdúch, M. - Sarek, J.
    Synthesis and Evaluation of Biological Activity of the Quaternary Ammonium Salts of Lupane-, Oleanane-, and Ursane-Type Acids.
    Synthesis. Roč. 42, č. 22 (2010), s. 3839-3848 ISSN 0039-7881
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: amines * terpenoids * esters
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 2.260, rok: 2010

    The anticancer properties of the derivatives of natural pentacyclic triterpenoids have received much attention recently. Here we present the preparation and the evaluation of the anticancer activity of a novel group of derivatives: quaternary ammonium esters. The esters were synthesized by quaternization of the respektive 2-bromoethyl esters of betulinic, dihydrobetulinic, platanic, oleanolic, ursolic, and 3b-acetoxy-21-oxolup-18-en-28-oic acids with common low-molecular-weight tertiary amines, namely trimethylamine, triethylamine, pyridine, and triethanolamine
    Trvalý link: http://hdl.handle.net/11104/0192297