Počet záznamů: 1

Analgesic compounds from Scorzonera latifolia (Fisch. and Mey.) DC

  1. 1.
    0352143 - UOCHB-X 2011 RIV IE eng J - Článek v odborném periodiku
    Bahadir, Ö. - Citoglu, G. S. - Šmejkal, K. - Dall Acqua, S. - Özbek, H. - Cvačka, Josef - Žemlička, M.
    Analgesic compounds from Scorzonera latifolia (Fisch. and Mey.) DC.
    Journal of Ethnopharmacology. Roč. 131, č. 1 (2010), s. 83-87 ISSN 0378-8741
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: Scorzonera latifolia * analgesic activity * triterpenes
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 2.466, rok: 2010

    A traditional mastic named yakı sakızı prepared from the roots of Scorzonera latifolia DC. is used as a folk remedy for treatment of pain in Turkish folk medicine. The extract of the S. latifolia roots was prepared and subjected to isolation procedures. Writhing and tail-flick tests were used to determine the antinociceptive activity. The n-hexane fraction of the S. latifolia root methanolic extract showed potent antinociceptiveactivity in both writhing and tail-flick tests. Three compounds were isolated using bioassay-guided chromatographic purification. Isolated compounds were triterpene taraxasteryl myristate, taraxasteryl acetate, and fern-7-en-3-b-one, structures were elucidated by means of MS and NMR techniques. Both taraxasterol derivatives showed promising antinociceptive activity when compared to reference compounds. The root extract and the isolated compounds showed promising antinociceptive activities.
    Trvalý link: http://hdl.handle.net/11104/0191723