Počet záznamů: 1

Modeling of nucleolar self-assembly

  1. 1.
    0351861 - UEM-P 2011 RIV CZ eng C - Konferenční příspěvek (zahraniční konf.)
    Blažíková, Michaela - Heřman, P. - Malínský, Jan
    Modeling of nucleolar self-assembly.
    MS'10 Prague. Prague: Czech Technical University, 2010, s. 34-37. ISBN 978-80-01-04574-9.
    [Proceedings of the International Conference on Modelling and Simulation 2010. Praha (CZ), 22.06.2010-25.06.2010]
    Grant CEP: GA ČR GA204/07/0133
    Grant ostatní: GA AV ČR(CZ) KAN200520801; GA MŠk(CZ) 0021620835
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: Monte Carlo simulations
    Kód oboru RIV: EB - Genetika a molekulární biologie

    Mammalian cell nucleoli disassemble at the beginning of mitosis and reassemble again during telophase and the early G1. Dynamics of this process was studied using a model based on entropy driven self-assembly of pre-ribosomal particles generated in a single biosynthetic source. Monte Carlo simulations revealed that such model can explain formation of a large aggregate, a nucleolus, in the vicinity of the source. We examined influence of nucleoplasm properties on dynamics of the aggregate formation.
    Trvalý link: http://hdl.handle.net/11104/0191512