Počet záznamů: 1

Numerical modelling of microRNA-mediated mRNA decay identifies novel mechanism of microRNA controlled mRNA downregulation

  1. 1.
    0351524 - MBU-M 2011 RIV GB eng J - Článek v odborném periodiku
    Vohradský, Jiří - Pánek, Josef - Vomastek, Tomáš
    Numerical modelling of microRNA-mediated mRNA decay identifies novel mechanism of microRNA controlled mRNA downregulation.
    Nucleic Acids Research. Roč. 38, č. 14 (2010), s. 4579-4585 ISSN 0305-1048
    Grant CEP: GA ČR GA310/07/1009; GA ČR GA303/09/0475; GA AV ČR IAA500200716
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: GENE-REGULATION * TRANSLATIONAL REPRESSION * TARGET PREDICTIONS
    Kód oboru RIV: EE - Mikrobiologie, virologie
    Impakt faktor: 7.836, rok: 2010

    A numerical model of miRNAmediated mRNA downregulation and its application to analysis of temporal microarray data of HepG2 cells transfected with miRNA-124a. Using the model analysis revealed a novel mechanism of mRNA accumulation control by miRNA, predicting that specific mRNAs are controlled in a digital, switch-like manner
    Trvalý link: http://hdl.handle.net/11104/0191260