Počet záznamů: 1

RTX proteins: a highly diverse family secreted by a common mechanism

  1. 1.
    0351522 - MBU-M 2011 RIV US eng J - Článek v odborném periodiku
    Linhartová, Irena - Bumba, Ladislav - Mašín, Jiří - Basler, Marek - Osička, Radim - Kamanová, Jana - Procházková, Kateřina - Adkins, Irena - Hejnová-Holubová, Jana - Sadílková, Lenka - Morová, Jana - Šebo, Peter
    RTX proteins: a highly diverse family secreted by a common mechanism.
    FEMS Microbiology Reviews. Roč. 34, č. 6 (2010), s. 1076-1112 ISSN 0168-6445
    Grant CEP: GA AV ČR IAA500200914; GA MŠk 2B06161; GA MŠk 1M0506; GA AV ČR KAN200520702; GA ČR GA310/08/0447; GA ČR GP310/09/P582; GA ČR GP310/07/P115; GA ČR GP204/07/P105
    Výzkumný záměr: CEZ:AV0Z50200510; CEZ:AV0Z50520701
    Klíčová slova: bacterial toxin * type I secretion system * RTX locus
    Kód oboru RIV: EE - Mikrobiologie, virologie
    Impakt faktor: 11.796, rok: 2010

    Repeats-in-toxin (RTX) exoproteins of Gram-negative bacteria form a steadily growing family of proteins with diverse biological functions. Their common feature is the unique mode of export across the bacterial envelope via the type I secretion system and the characteristic, typically nonapeptide, glycine- and aspartate-rich repeats binding Ca ions. In this review, we summarize the current state of knowledge on the organization of rtx loci and on the biological and biochemical activities of therein encoded proteins. Applying several types of bioinformatic screens on the steadily growing set of sequenced bacterial genomes, over 1000 RTX family members were detected, with the biological functions of most of them remaining to be characterized
    Trvalý link: http://hdl.handle.net/11104/0191258