Počet záznamů: 1

Synthesis of C-6-substituted uridine phosphonates through aerobic ligand-free Suzuki-Miyaura cross-coupling

  1. 1.
    0351450 - UOCHB-X 2011 RIV GB eng J - Článek v odborném periodiku
    Nencka, Radim - Sinnaeve, D. - Karalic, I. - Martins, J. C. - Calenbergh, Van S.
    Synthesis of C-6-substituted uridine phosphonates through aerobic ligand-free Suzuki-Miyaura cross-coupling.
    Organic & Biomolecular Chemistry. Roč. 8, č. 22 (2010), s. 5234-5246 ISSN 1477-0520
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: ligand-free * Suzuki-Miyaura cross-coupling * phosphonate
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 3.451, rok: 2010

    An efficient protocol for the construction of C-6-(hetero)aryl-substituted uridine phosphonate analogues utilizing an aerobic, ligand-free Suzuki–Miyaura cross-coupling reaction of a 6-iodo-precursor in aqueous media has been established. The method presents a modular approach toward the target compounds as demonstrated by the synthesis of a small library comprising 14 novel nucleoside phosphonates.
    Trvalý link: http://hdl.handle.net/11104/0191204