Počet záznamů: 1

Melectin MAPs: the influence of dendrimerization on antimicrobial and hemolytic activity

  1. 1.
    0351324 - UOCHB-X 2011 RIV AT eng J - Článek v odborném periodiku
    Niederhafner, Petr - Bednárová, Lucie - Buděšínský, Miloš - Šafařík, Martin - Ehala, Sille - Ježek, Jan - Borovičková, Lenka - Fučík, Vladimír - Čeřovský, Václav - Slaninová, Jiřina
    Melectin MAPs: the influence of dendrimerization on antimicrobial and hemolytic activity.
    Amino Acids. Roč. 39, č. 5 (2010), s. 1553-1561 ISSN 0939-4451
    Grant CEP: GA ČR GA203/03/1362; GA ČR GA203/09/1919
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: melectin * antibacterial peptides * dendrimers * hemolytic activity
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 4.106, rok: 2010

    The influence of dimerization and tetramerization of peptide melectin (GFLSILKKVLPKVMAHMK-NH2) on its antimicrobial and hemolytic activities, as well as the role of Met in positions 14 and 17 of its peptide chain, was studied. 23 new analogues were synthesized. Dimerization and tetramerization increased the undesirable hemolytic activity. Introduction of the isosteric amino acid Nle into positions 14 or 17 or both led to only slight increase of hemolytic activity under preservation of high antimicrobial activities. Substitution of Leu for Val in position 6 led to the decrease of hemolytic activity.
    Trvalý link: http://hdl.handle.net/11104/0191102