Počet záznamů: 1

Nitro-fatty acids reduce atherosclerosis in apolipoprotein E-deficient mice

  1. 1.
    0351174 - BFU-R 2011 RIV US eng J - Článek v odborném periodiku
    Rudolph, T.K. - Rudolph, V. - Edreira, M.M. - Cole, M.P. - Bonacci, G. - Schopfer, F.J. - Woodcock, S.R. - Franek, A. - Pekarová, Michaela - Khoo, N.K.H. - Hasty, A.H. - Baldus, S. - Freeman, B.A.
    Nitro-fatty acids reduce atherosclerosis in apolipoprotein E-deficient mice.
    Arteriosclerosis Thrombosis and Vascular Biology. Roč. 30, č. 5 (2010), s. 938-945 ISSN 1079-5642
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: nitro-fatty acids * atherosclerosis * foam cells
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 7.215, rok: 2010

    Inflammatory processes and foam cell formation are key determinants in the initiation and progression of atherosclerosis. Electrophilic nitro-fatty acids, byproducts of nitric oxide- and nitrite-dependent redox reactions of unsaturated fatty acids, exhibit antiinflammatory signaling actions in inflammatory and vascular cell model systems. The in vivo action of nitro-fatty acids in chronic inflammatory processes such as atherosclerosis remains to be elucidated.
    Trvalý link: http://hdl.handle.net/11104/0190981