Počet záznamů: 1

Nanostructured complexes of polyelectrolytes and charged polypeptides

  1. 1.
    0350917 - UMCH-V 2011 RIV DE eng J - Článek v odborném periodiku
    Müller, M. - Ouyang, W. - Bohatá, Karolína - Kessler, B.
    Nanostructured complexes of polyelectrolytes and charged polypeptides.
    Advanced Engineering Materials. Roč. 12, Sp. Iss. 9 (2010), B519-B528 ISSN 1438-1656.
    [Sino-German Symposium on Advanced Biomedical Nanostructures /1./. Jena, 26.10.2009-30.10.2009]
    Výzkumný záměr: CEZ:AV0Z40500505
    Klíčová slova: situ ATR-FTIR * alpha-helical polypeptides * multilayer films
    Kód oboru RIV: CD - Makromolekulární chemie
    Impakt faktor: 1.746, rok: 2010

    Nanoparticles and films of complexes between polyelectrolytes (PELs) and oppositely charged polypeptides emphasizing the influence of PEL molecular stiffness on the generated nanostructures are reported. Homopolypeptides like cationic poly(L-lysine) (PLL) and anionic poly(L-glutamic acid) (PLG) were used, whose conformations can be changed from random coil to α-helix by salt type or pH value. Randomly coiled PLL caused spherical PEC particles and isotropically structured PEM films. For PEM films consisting of PDADMAC/PLG PLG terminating PEM-6 was proteininert, while PDADMAC terminating PEM-7 was proteinactive. PEM films consisting of PDL/PSS showed higher enantiospecific adsorption of α-helical myoglobin compared to PLL/PSS. These nanoparticles and films are envisioned as bioinert and bioactive material substrates, unidirectional cell growth, polymer/cell scaffolds, and nanocarriers.
    Trvalý link: http://hdl.handle.net/11104/0006153