Počet záznamů: 1

Time-resolved FRET between GPCR ligands reveals oligomers in native tissues

  1. 1.
    0350688 - UEM-P 2011 RIV US eng J - Článek v odborném periodiku
    Albizu, L. - Cottet, M. - Králíková, Michaela - Stoev, S. - Steyer, R. - Brabet, I. - Roux, T. - Bazin, H. - Bourrier, E. - Lamarque, L. - Breton, C. - Rives, M. L. - Newman, A. H. - Javitch, J. A. - Trinquet, E. - Manning, M. - Pin, J. P. - Mouillac, B. - Durroux, T.
    Time-resolved FRET between GPCR ligands reveals oligomers in native tissues.
    Nature Chemical Biology. Roč. 6, č. 8 (2010), s. 587-594 ISSN 1552-4450
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: G protein-coupled receptor * FRET
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 15.808, rok: 2010

    The artical "Time-resolved FRET between GPCR ligands reveals oligomers in native tissues" shows for the first time that G-protein coupled receptors (GPCRs) form oligomeric complexes also in native tissues and not only in heterologous expression systems. Oligomerization of these receptors regulates their function and pharmacological properties and thus influences all the processes controled by GPCRs that are involved in the cell response to extracellular stimuli.
    Trvalý link: http://hdl.handle.net/11104/0190624