Počet záznamů: 1

Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents

  1. 1.
    0350272 - UOCHB-X 2011 RIV US eng J - Článek v odborném periodiku
    Krečmerová, Marcela - Holý, Antonín - Andrei, G. - Pomeisl, Karel - Tichý, Tomáš - Břehová, Petra - Masojídková, Milena - Dračínský, Martin - Pohl, Radek - Laflamme, G. - Naesens, L. - Hui, H. - Cihlař, T. - Neyts, J. - De Clercq, E. - Balzarini, J. - Snoeck, R.
    Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents.
    Journal of Medicinal Chemistry. Roč. 53, č. 19 (2010), s. 6825-6837 ISSN 0022-2623
    Grant CEP: GA MŠk 1M0508; GA MŠk(CZ) ME10040
    Grant ostatní: NIH(US) 1UC1 AI062540-01
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: phosphonates * prodrugs * poxvirus * herpes virus * bioterrorism
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 5.207, rok: 2010

    The following structurally diverse types of esters of (S)-HPMPDAP and its cyclic form were prepared: alkoxyalkyl, pivaloyloxymethyl (POM), 2,2,2-(trifluoro)ethyl, butylsalicylyl, and ester bound peptidomimetics. The activity was evaluated not only against vaccinia virus but also against different herpesviruses. The most potent and active prodrugs against vaccinia virus were the alkoxyalkyl ester derivatives followed by POM esters.
    Trvalý link: http://hdl.handle.net/11104/0190312