Počet záznamů: 1

CycloSal-Phosphate Pronucleotides of Cytostatic 6-(Het)aryl-7-Deazapurine Ribonucleosides: Synthesis, Cytostatic Activity, and Inhibition of Adenosine Kinases

  1. 1.
    0350071 - UOCHB-X 2011 RIV DE eng J - Článek v odborném periodiku
    Spáčilová, Pavla - Nauš, Petr - Pohl, Radek - Votruba, Ivan - Snášel, Jan - Zábranská, Helena - Pichová, Iva - Ameral, R. - Birkuš, G. - Cihlař, T. - Hocek, Michal
    CycloSal-Phosphate Pronucleotides of Cytostatic 6-(Het)aryl-7-Deazapurine Ribonucleosides: Synthesis, Cytostatic Activity, and Inhibition of Adenosine Kinases.
    ChemMedChem. Roč. 5, č. 8 (2010), s. 1386-1396 ISSN 1860-7179
    Grant CEP: GA MŠk 1M0508
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: nucleosides * pronucleotides * deazapurines * cytostatics
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 3.306, rok: 2010

    A series of cycloSal-phosphate prodrugs of a recently described new class of nucleoside cytostatics (6-hetaryl-7-deazapurine ribonucleosides) was prepared. The in vitro cytostatic effect of the pronucleotides was compared with parent nucleoside analogues. In most cases, the activity of the pronucleotide was similar to or somewhat lower than that of the corresponding parent nucleosides.
    Trvalý link: http://hdl.handle.net/11104/0190164