Počet záznamů: 1

Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy

  1. 1.
    0349834 - UEB-Q 2011 RIV US eng P - Patentový dokument
    Moravcová, Daniela - Havlíček, Libor - Kryštof, Vladimír - Lenobel, René - Strnad, Miroslav
    Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy.
    USA: United States Patent and Trademark Office, 2010. Vlastník: Ústav experimentální botaniky AV ČR, v. v. i., Univerzita Palackého v Olomouci. Datum podání přihlášky: 28.09.2004. Datum udělení patentu: 29.06.2010. Číslo patentu: US7745450
    Grant CEP: GA ČR GA301/08/1649; GA ČR GA522/09/1576
    Klíčová slova: pyrazolo[4,3-d]pyrimidines * anticancer * anti-inflamatory
    Kód oboru RIV: FD - Onkologie a hematologie

    The invention relates to new trisubstituted pyrazolo[4,3-d]pyrimidine derivatives and to their use in suitable utilities, especially diagnostic and therapeutic methods.The compounds are anticancer, anti-inflammatory, antiviral, antineurodegenerative, neurodepressive and immunosuppressive, they have improved selectivity and efficiency index, i.e. that are less toxic yet more efficacious than analogues known.It is an object of this invention to provide 3-, 5-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines, which inhibit the cdks, cell proliferation, and/or induce apoptosis. A further object of the invention is to provide a method for inhibiting cell proliferation and inflammatory diseases to a mammal in need of an effective amount.The solution of this object are 3-, 5-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines of the formula I.
    Trvalý link: http://hdl.handle.net/11104/0189973