Počet záznamů: 1

Inhibition of gap-junctional intercellular communication and activation of mitogen-activated protein kinases by cyanobacterial extracts-Indications of novel tumor-promoting cyanotoxins?

  1. 1.
    0349719 - BU-J 2011 RIV GB eng J - Článek v odborném periodiku
    Bláha, Luděk - Babica, Pavel - Hilscherová, Klára - Upham, B. L.
    Inhibition of gap-junctional intercellular communication and activation of mitogen-activated protein kinases by cyanobacterial extracts-Indications of novel tumor-promoting cyanotoxins?.
    Toxicon. Roč. 55, č. 1 (2010), s. 126-134 ISSN 0041-0101
    Grant CEP: GA ČR GA524/08/0496
    Výzkumný záměr: CEZ:AV0Z60050516
    Klíčová slova: liver tumor promotion * cyanobacteria * microcystin
    Kód oboru RIV: EF - Botanika
    Impakt faktor: 2.451, rok: 2010

    Gap-junctional intercellular communication (GJIC) and mitogen-activated protein kinases (MAPKs), well-established biomarkers of tumor promotion, were affected by cyanobacterial extracts in in vitro experiments with rat liver epithelial cells. Since the observed effects of cyanobacterial extracts did not correlate with the content of known hepatotoxic cyanotoxins, and the pure toxins (microcystin, cylindrospermopsin, lipopolysaccharides) affected neither GJIC nor MAPKs, the effects were most likely induced by not-yet characterized chemicals of produced by cyanobacteria. These mechanisms (inhibition of GJIC, activation of MAPKs) and chemicals may thus contribute to the tumor promoting activity of toxic cyanobacteria.
    Trvalý link: http://hdl.handle.net/11104/0189880