Počet záznamů: 1

Association between exposure-relevant polymorphisms in CYP1B1, EPHX1, NQO1, GSTM1, GSTP1 and GSTT1 and risk of colorectal cancer in a Czech population

  1. 1.
    0349496 - UEM-P 2011 RIV GR eng J - Článek v odborném periodiku
    Hlavatá, I. - Vrána, D. - Šmerhovský, Z. - Pardini, Barbara - Naccarati, Alessio - Vodička, Pavel - Novotný, J. - Mohelníková-Duchoňová, B. - Souček, P.
    Association between exposure-relevant polymorphisms in CYP1B1, EPHX1, NQO1, GSTM1, GSTP1 and GSTT1 and risk of colorectal cancer in a Czech population.
    Oncology Reports. Roč. 24, č. 5 (2010), s. 1347-1353 ISSN 1021-335X
    Grant CEP: GA ČR GA310/07/1430
    Grant ostatní:GA MŠk(CZ) GAUK15109/2009; GA MZd(CZ) NS10230
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: colorectal cancer * cytochrome P450 * polymorphism
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 1.686, rok: 2010

    The glutathione S-transferase Mu-1 deletion was associated with a moderately elevated colorectal cancer risk (aOR=1.30, CI=1.01-1.68, p=0.044). Combination of glutathione Stransferase Mu-1 and ı-1 deletion was associated with a significantly higher colorectal cancer risk compared to the presence of both full-length genes (aOR=1.58, CI=1.01-2.47, p=0.044). These results provide further evidence that interaction between metabolic gene variants contributes to colorectal carcinogenesis.
    Trvalý link: http://hdl.handle.net/11104/0189716