Počet záznamů: 1

Astrocytes in Alzheimer's Disease

  1. 1.
    0349472 - UEM-P 2011 RIV US eng J - Článek v odborném periodiku
    Verkhratsky, Alexei - Olabarria, M. - Noristani, H. N. - Yeh, C. Y. - Rodríguez Arellano, Jose Julio
    Astrocytes in Alzheimer's Disease.
    Neurotherapeutics. Roč. 7, č. 4 (2010), s. 399-412 ISSN 1933-7213
    Grant CEP: GA ČR GA309/09/1696; GA ČR GA305/08/1384
    Výzkumný záměr: CEZ:AV0Z50390703
    Klíčová slova: Astrocytes * neuroglia * neurodegeneration
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 6.084, rok: 2010

    In this manuscript we covered the specific involvement of astrocytes in various neurodegenerative diseases including Alzheimer's disease, Amyotrophic lateral sclerosis, Parkinson's disease and various forms of dementia. We demonstrate that early stages of neurodegenerative processes are associated with atrophy of astroglia, which causes disruptions in synaptic connectivity, disbalance in neurotransmitter homeostasis and neuronal death through increased excitotoxicity. Which at the later stages astrocytes became activated and contribute to neuro-inflammatory component of neurodegeneration.
    Trvalý link: http://hdl.handle.net/11104/0189705