Počet záznamů: 1
Astrocytes in Alzheimer's Disease
0349472 - UEM-P 2011 RIV US eng J - Článek v odborném periodiku
Verkhratsky, Alexei - Olabarria, M. - Noristani, H. N. - Yeh, C. Y. - Rodríguez Arellano, Jose Julio
Astrocytes in Alzheimer's Disease.
Neurotherapeutics. Roč. 7, č. 4 (2010), s. 399-412 ISSN 1933-7213
Grant CEP: GA ČR GA309/09/1696; GA ČR GA305/08/1384
Výzkumný záměr: CEZ:AV0Z50390703
Klíčová slova: Astrocytes * neuroglia * neurodegeneration
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 6.084, rok: 2010
In this manuscript we covered the specific involvement of astrocytes in various neurodegenerative diseases including Alzheimer's disease, Amyotrophic lateral sclerosis, Parkinson's disease and various forms of dementia. We demonstrate that early stages of neurodegenerative processes are associated with atrophy of astroglia, which causes disruptions in synaptic connectivity, disbalance in neurotransmitter homeostasis and neuronal death through increased excitotoxicity. Which at the later stages astrocytes became activated and contribute to neuro-inflammatory component of neurodegeneration.
Trvalý link: http://hdl.handle.net/11104/0189705