Počet záznamů: 1

The effect of low dose of vinclozolin on reproductive tract development and sperm parameters in CD1 outbred mice

  1. 1.
    0349100 - BTO-N 2011 RIV ES eng C - Konferenční příspěvek (zahraniční konf.)
    Pěknicová, Jana - Elzeinová, Fatima - Nováková, Vendula - Buckiová, Daniela - Kubátová, Alena
    The effect of low dose of vinclozolin on reproductive tract development and sperm parameters in CD1 outbred mice.
    Journal of Andrology - 9th International Congress of Andrology. Barcelona: The American Society, 2009, s. 54-55 ISSN 0196-3635.
    [9th International Congress of Andrology. Barcelona (ES), 07.03.2009-10.03.2009]
    Grant CEP: GA MŠk(CZ) 1M06011; GA MŠk(CZ) 2B06151
    Výzkumný záměr: CEZ:AV0Z50520701; CEZ:AV0Z50390703
    Klíčová slova: vinclozolin * spermatozoa * anti-androgen
    Kód oboru RIV: DN - Vliv životního prostředí na zdraví

    The effect of a low dose of vinclozolin within the development of the reproductive tract during gestation (VIN-GD 15-22) and puberty (VIN-PND 23-44) in CD1 mice was tested. We found a decrease in the anogenital distance, prostate weight and pathology of testes in both experimental groups. Sperm counts decreased to 46% (VIN-GD) and to 81% (VIN-PND), and also the acrosomal state (evaluated by antiacrosomal antibody) decreased in both groups to 89% in comparison to the control group (100%). Sperm head abnormalities increased by approximately 18% and 13%, respectively. In this connection, the expression of some genes was changed (arosome-related gene (Acr), apoptosis related genes (p53, p21)). In conclusion, a low dose of vinclozolin affected the reproductive tract, sperm parameters and expression of selected genes in both experimental groups.
    Trvalý link: http://hdl.handle.net/11104/0189429