Počet záznamů: 1

Impact of Global Cerebral Ischemia on K(+) Channel Expression and Membrane Properties of Glial Cells in the Rat Hippocampus

  1. 1.
    0349049 - UEM-P 2011 RIV GB eng J - Článek v odborném periodiku
    Pivoňková, Helena - Benešová, Jana - Butenko, Olena - Chvátal, Alexandr - Anděrová, Miroslava
    Impact of Global Cerebral Ischemia on K(+) Channel Expression and Membrane Properties of Glial Cells in the Rat Hippocampus.
    Neurochemistry International. Roč. 57, č. 7 (2010), s. 783-794 ISSN 0197-0186
    Grant CEP: GA ČR GA305/09/0717; GA ČR GAP303/10/1338; GA MŠk(CZ) LC554
    Grant ostatní: GA MŠk(CZ) 1M0538
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: CNS injury * Patch-clamp * K+ channels
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 3.601, rok: 2010

    Using patch-clamp technique and immunohistochemical analysis, we investigated the changes in the expression of K+ channels in the rat hippocampal astrocytes and NG2-glia following global cerebral ischemia. We showed that the membrane properties of astrocytes after ischemia undergo complex alterations profoundly influencing the maintenance of K+ homeostasis in the damaged tissue, while NG2 glia display membrane currents typical of proliferating cells.
    Trvalý link: http://hdl.handle.net/11104/0189389