Počet záznamů: 1

Bral1: Its Role in Diffusion Barrier Formation and Conduction Velocity in the CNS

  1. 1.
    0348934 - UEM-P 2011 RIV US eng J - Článek v odborném periodiku
    Bekku, Y. - Vargová, Lýdia - Goto, Y. - Voříšek, Ivan - Dmytrenko, Lesia - Narasaki, M. - Ohtsuka, A. - Fässler, R. - Ninomiya, Y. - Syková, Eva - Oohashi, T.
    Bral1: Its Role in Diffusion Barrier Formation and Conduction Velocity in the CNS.
    Journal of Neuroscience. Roč. 30, č. 8 (2010), s. 3113-3123 ISSN 0270-6474
    Grant CEP: GA ČR GA309/09/1597
    Grant ostatní: GA MŠk(CZ) 1M0538; GA MZd(CZ) NS9915
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: Bral1 * central nervous system * brain development
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 7.271, rok: 2010

    Brain-specific hyaluronan-binding link protein, Bral1, colocalizes and forms complexes with negatively charged extracellular matrix (ECM) proteins at the nodes of Ranvier in the myelinated white matter. The study report that the ECM no longer shows a nodal pattern and that CNS nerve conduction is markedly decreased in Bral1-deficient mice and the changes in the extracellular space diffusion parameters, measured by the real-time iontophoretic method and diffusion-weighted magnetic resonance imaging (MRI), suggest a reduction in the diffusion hindrances in the white matter of mutant mice.
    Trvalý link: http://hdl.handle.net/11104/0189315