Počet záznamů: 1

Allosteric Modulation of Muscarinic Acetylcholine Receptors

  1. 1.
    0348428 - FGU-C 2011 RIV CH eng J - Článek v odborném periodiku
    Jakubík, Jan - El-Fakahany, E. E.
    Allosteric Modulation of Muscarinic Acetylcholine Receptors.
    Pharmaceuticals. Roč. 3, č. 9 (2010), s. 2838-2860 ISSN 1424-8247
    Grant CEP: GA ČR GA305/09/0681
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: muscarinic acetylcholine receptors * allosteric modulation * Alzheimer´s disease
    Kód oboru RIV: CE - Biochemie

    This review summarizes over 30 years of reserch on the molecular mechanisms of allosteric interactions of drugs with the receptor and for new allosteric modulators of muscarinic receptors with potential therapeutic use. Identification of positive modulators of acetylcholine binding and function that enhance neurotransmission and the discovery of highly selective allosteric modulators are mile-stones on the way to novel therapeutic agents for the treatment of schizophrenia, Alzheimer´s disease and other involving impaired cognitive function
    Trvalý link: http://hdl.handle.net/11104/0188969