Počet záznamů: 1

Long-term adaptation to high doses of morphine causes desensitization of micro-OR- and delta-OR-stimulated G-protein response in forebrain cortex but does not decrease the amount of G-protein alpha subunits

  1. 1.
    0348192 - FGU-C 2011 RIV US eng J - Článek v odborném periodiku
    Bouřová, Lenka - Vošahlíková, Miroslava - Kagan, D. - Dlouhá, Kateřina - Novotný, J. - Svoboda, Petr
    Long-term adaptation to high doses of morphine causes desensitization of micro-OR- and delta-OR-stimulated G-protein response in forebrain cortex but does not decrease the amount of G-protein alpha subunits.
    Medical Science Monitor. Roč. 16, č. 8 (2010), BR260-BR270 ISSN 1234-1010
    Grant CEP: GA AV ČR(CZ) IAA500110606; GA MŠk(CZ) LC554
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: morphine * G-protein * opioid receptors
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 1.699, rok: 2010

    Our data support the view that the mechanism of the long-term adaptation to high doses of morphine is primarily based on desensitization of opioid receptors-response preferentially oriented to micro- and delta-opioid receptors. Prolonged exposure of rats to high doses of morphine results in decrease of the over-all output of opioid receptors-stimulated G-protein activity in the forebrain cortex but does not decrease the amount of these regulatory proteins
    Trvalý link: http://hdl.handle.net/11104/0188782